EXP 2020.11.19 or More, Korean Manual
Facts about deworming :
Worm infestation is very common health problem. Parasitic worms like round worm, pin worm, hook worm etc spread to humans through untidy hands, unhygienic practices and poor sanitation facilities.
For instance, a simple lick from your pet, a barefoot walk on your lawn, a swim in a reservoir or a pool with untreated water or negligence on your part to wash hands thoroughly before eating or preparing food after gardening or unwashed salad or untreated drinking water or milk or fluids or under cooked meat or school going children in your family can bring the eggs from these parasites.
These small worms are barely visible to the naked eye, but the discomfort level and illnesses caused are varied in intensity and seriousness. An untreated worm infestation can even result in the host’s death.
Hundreds of millions of children worldwide are infected with parasitic worms. Remember that these worms are detrimental to your child’s health, their cognitive development, their education and a brighter future.
Chronic illness caused by worm infections reduces literacy and thus adult productivity thereby impacting on the economic development of low and middle income countries. Deworming is a process which helps get rid of worms that enter the human body.
We provide you with a list of seven facts that you need to know about the all-pervading worm infestation and getting rid of it via deworming:
- Not only children but adults too are prone to worm infestations
- Children above two years of age should be put under a regular routine of deworming to maintain good health
- Worms enter the body due to lack of hygiene
- The most common infestation are caused by the round worm, tape worm and hook worms
- Lack of appetite, tiredness, anaemia, loose bowels, vomiting is all some common symptoms of worm infestation
- Deworming every four to six months is the suggested frequency
400 mg suspension as a single dose in both adults and children over two years of age. The tablets may be crushed, chewed, swallowed or crushed and mixed with food. In heavy mixed infestation involving Strongyloides or Taeniasis, a single daily dose may be inadequate and the dose may be given for three consecutive days.
The chemical name of albendazole is methyl [5-(propylthio)-1H-benzimidazol-2-yl] carbamate.
Each ZENTEL 400 mg tablet contains 400 mg albendazole.
The suspension contains 100 mg albendazole in each 5 mL, preserved with potassium sorbate 0,39% m/v, benzoic acid 0,2% m/v, sorbic acid 0,08% m/v and aspartame.
Manufacturer of Zentel Tablets: GlaxoSmithKline Pharmaceuticals Limited
Manufacturer of Bandy Tablets: yuhan corporation Korea(south)
Albendazole is a benzimidazole carbamate with anthelmintic and antiprotozoal activity against intestinal and tissue parasites. Animal studies have shown that albendazole exhibits vermicidal, ovacidal and larvacidal activity and exerts its anthelmintic effect by inhibiting tubulin polymerization. This causes the disruption of the helminth metabolism, including energy depletion, which immobilises and then kills the susceptible helminth. In man, after oral administration, albendazole is absorbed and completely metabolized. At a dose of 6,6 mg/kg of albendazole the plasma concentration of its main metabolite, the sulfoxide, attains a maximum of 0,25 to 0,30 micrograms/mL after approximately 2½ hours. The half-life of the sulfoxide in the plasma is 8% hours. The metabolite is essentially eliminated via the urine,
It has been noted that leucopaenia has occurred when used for periods longer than recommended.
In order to avoid administering albendazole during early pregnancy, women of childbearing age should initiate treatment during the first week of menstruation or after a negative pregnancy test.
ZENTEL is indicated in the treatment of single or mixed intestinal parasites. Clinical studies have shown albeneffective in the treatment of Ascaris lumbricoides (roundworm), Trichuris trichiura (whipworm), Enterobius vermicularis (pinworm/threadworm), Ancylostoma duodenale and Necator americanus (hookworm), Taenia spp. (tapeworm) and Strongyloides stercoralis.
ZENTEL has been shown to be effective in the treatment of Giardia (duodenalis or intestinalis or lamblia) infections in children.
Albendazole is known to be teratogenic and embryotoxic in animals. The safety of albendazole during pregnancy has not been established, and ZENTEL should not be taken by pregnant women at any stage of their pregnancy or by women who are likely to become pregnant, during or shortly after the course of therapy. ZENTEL is contra-indicated in patients with a known history of hypersensitivity to albendazole or constituents.
If the patient is not cured after three weeks, a second course of treatment may be given. No special procedures, such as fasting or purging, are required.
Albendazole has not been adequately studied in children under one year of age.
Giardiasis (dose in children over 2 years of age):
A single 400 mg daily dose for five days.
The tablets may be chewed, swallowed or crushed and they should be taken with food.
SIDE-EFFECTS AND SPECIAL PRECAUTIONS:
Gastrointestinal discomfort, diarrhoea, headache and dizziness have been reported.
Hypersensitivity reactions including rash. pruritus and urticaria have been reported less frequently.
Praziquantel has been reported to increase the plasma levels of the albendazole active metabolite.
KNOWN SYMPTOMS OF OVERDOSAGE AND PARTICULARS OF ITS TREATMENT:
If poisoning or excessive overdosage is suspected it is recommended, on general principles, that vomiting be induced or gastric lavage be performed, and such symptomatic supportive therapy be administered as appears indicated.
Store in a cool place (below 25°C). Protect suspension from light.
KEEP OUT OF REACH OF CHILDREN.